I've been hacking on it all day for work and overall I'm really happy. I've always been a fan so I guess it's to be expected.
The keyboard...it's a mixed bag.
The positive is that it feels very very solid. There's less 'wiggle' in the keys than my 201. The shape is a different feel, and it'll take getting used to. I find my speed isn't impacted, but I do feel like the keys are farther apart. I feel a lot as I do when typing on my unicomp I use when docked.
The keys do have a good 'noise' as I'm a heavy banger of the keys. Nothing better than my unicomp springs begging for mercy.

It is different, more thud than 'clack' like the 201 was.
The bad: I've missed the escape key while hacking in vim about 100 times today because it's lower now that the top row is gone. I have to hunt for the home/end keys because they're just blended into that row. Delete is strange, but it was moved in the 220 as well so I can't complain much on that end.
The lowered trackpoint I think is ok. It's different, but I haven't found myself having issues as I've used it all day.
The screen is just awesome, can't say that enough. That alone makes me so happy I upgraded. Between that and the intel 520 I put in here, speed is just great. I feel like things are a nice burst faster for me. I miss not having to deal with the trackpad though, great feature of the 201 was that I could just leave the dippy thing off.
The battery feels a bit more loose then on the 201. When I've carried it around I swear I've felt it shift around.
The usb ports seem to be a bit more 'deep' into the case. I've got a yubikey nano I use for my 2-factor needs that I can just barely touch the point on when I need to. Watch out for that I guess.
I tried to use the camera for my stand up meeting today but ugh it wasn't pretty. I'm using it with google hangouts in linux, but my external logitechs are much better so it'll be an emergency only camera for my purposes.
Finally, the power button on the dock doesn't work to power on the laptop. I'm kind of bummed as I have to open the lid, reach way under, and hit the power button on the laptop while trying not to bump the screen and leave a mark since I can't open the lid all the way. I've got monitors mounted on arms above the dock.
Hope that helps provide some more details. Let me know if you have any specific questions.